Jonathan Sleeman: The ins and outs of the molecular regulation of metastasis
Cancer metastasis is regulated both intrinsically, for example through genetic aberrations and perturbed gene expression patterns in tumor cells, as well as extrinsically through the extracellular microenvironment. Focusing on the immediate early gene Ier2 and the multi-domain scaffold protein ASAP1, my laboratory has recently explored molecular mechanisms within breast cancer and melanoma cells that regulate metastasis. In a model of cutaneous melanoma metastasis, we have also identified matrix assisted autocrine BMP signaling and subsequent expression of the transcriptional regulators Id1 and Id3 as a mechanism through which the extracellular microenvironment can promote metastasis initiation. Novel inhibitors of Id1 and Id3 that we have developed show therapeutic potential in this context. These data will be presented in the talk.
Zoom-link, Non-members of TRR 305 please contact: Stefanie.Pausch@ukr.de