Jean-Christophe Marine: Nongenetic mechanisms of cancer evolution and therapy resistance

Wednesday 7. July 2021, 15:00 Uhr

Chris Marine is Professor, senior VIB group leader and Director of the VIB/KULeuven center for Cancer Biology. He received numerous national and international awards and was elected EMBO member in 2020. His interests focus on the mechanisms by which cancer-specific non-mutational (i.e. epigenetic and (post-) transcriptional) events shape tumour evolution. Using innovative genetic tools and applying cutting-edge technologies the Marine lab has made several key contributions to our understanding of melanoma biology and, in particular, the mechanisms underlying melanoma initiation, growth, metastatic dissemination, emergence of inter-and intra-tumor heterogeneity, plasticity and resistance to therapy.

I will discuss recent observations from my lab highlighting the importance of nongenetic mechanisms as drivers of tumor growth, metastatic dissemination and resistance to targeted therapy.

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