Publikationen AG Klein

  • 2020

    Pfeil nach unten

    Werner-Klein, M., Grujovic, A., Irlbeck, C., Obradovic, M., Hoffmann, M., Koerkel-Qu, H., Lu, X., Treitschke, S., Kostler, C., Botteron, C., Weidele, K., Werno, C., Polzer, B., Kirsch, S., Guzvic, M., Warfsmann, J., Honarnejad, K., Czyz, Z., Feliciello, G., Blochberger, I., Grunewald, S., Schneider, E., Haunschild, G., Patwary, N., Guetter, S., Huber, S., Rack, B., Harbeck, N., Buchholz, S., Rummele, P., Heine, N., Rose-John, S., and Klein, C. A. (2020) Interleukin-6 trans-signaling is a candidate mechanism to drive progression of human DCCs during clinical latency. Nat Commun11, 4977

    Vollmann-Zwerenz, A., Leidgens, V., Feliciello, G., Klein, C. A., and Hau, P. (2020) Tumor Cell Invasion in Glioblastoma. Int J Mol Sci21

    Metzenmacher, M., Varaljai, R., Hegedus, B., Cima, I., Forster, J., Schramm, A., Scheffler, B., Horn, P. A., Klein, C. A., Szarvas, T., Reis, H., Bielefeld, N., Roesch, A., Aigner, C., Kunzmann, V., Wiesweg, M., Siveke, J. T., Schuler, M., and Lueong, S. S. (2020) Plasma Next Generation Sequencing and Droplet Digital-qPCR-Based Quantification of Circulating Cell-Free RNA for Noninvasive Early Detection of Cancer. Cancers (Basel)12

    Blazquez, R., Rietkotter, E., Wenske, B., Wlochowitz, D., Sparrer, D., Vollmer, E., Muller, G., Seegerer, J., Sun, X., Dettmer, K., Barrantes-Freer, A., Stange, L., Utpatel, K., Bleckmann, A., Treiber, H., Bohnenberger, H., Lenz, C., Schulz, M., Reimelt, C., Hackl, C., Grade, M., Buyuktas, D., Siam, L., Balkenhol, M., Stadelmann, C., Kube, D., Krahn, M. P., Proescholdt, M. A., Riemenschneider, M. J., Evert, M., Oefner, P. J., Klein, C. A., Hanisch, U. K., Binder, C., and Pukrop, T. (2020) LEF1 supports metastatic brain colonization by regulating glutathione metabolism and increasing ROS resistance in breast cancer. International journal of cancer146, 3170-3183

  • 2019

    Pfeil nach unten

    Werner-Klein, M., and Klein, C. A. (2019) Therapy resistance beyond cellular dormancy. Nature cell biology21, 117-119

    Weidele, K., Stojanovic, N., Feliciello, G., Markiewicz, A., Scheitler, S., Alberter, B., Renner, P., Haferkamp, S., Klein, C. A., and Polzer, B. (2019) Microfluidic enrichment, isolation and characterization of disseminated melanoma cells from lymph node samples. International journal of cancer145, 232-241

    Durst, F. C., Grujovic, A., Ganser, I., Hoffmann, M., Ugocsai, P., Klein, C. A., and Czyz, Z. T. (2019) Targeted transcript quantification in single disseminated cancer cells after whole transcriptome amplification. PloS one14, e0216442

    Alieva, M., Leidgens, V., Riemenschneider, M. J., Klein, C. A., Hau, P., and van Rheenen, J. (2019) Intravital imaging of glioma border morphology reveals distinctive cellular dynamics and contribution to tumor cell invasion. Sci Rep9, 2054

  • 2018

    Pfeil nach unten

    Werner-Klein, M., Scheitler, S., Hoffmann, M., Hodak, I., Dietz, K., Lehnert, P., Naimer, V., Polzer, B., Treitschke, S., Werno, C., Markiewicz, A., Weidele, K., Czyz, Z., Hohenleutner, U., Hafner, C., Haferkamp, S., Berneburg, M., Rummele, P., Ulmer, A., and Klein, C. A. (2018) Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma. Nat Commun9, 595

    Ulmer, A., Dietz, K., Werner-Klein, M., Hafner, H. M., Schulz, C., Renner, P., Weber, F., Breuninger, H., Rocken, M., Garbe, C., Fierlbeck, G., and Klein, C. A. (2018) The sentinel lymph node spread determines quantitatively melanoma seeding to non-sentinel lymph nodes and survival. European journal of cancer91, 1-10

    Luke, F., Blazquez, R., Yamaci, R. F., Lu, X., Pregler, B., Hannus, S., Menhart, K., Hellwig, D., Wester, H. J., Kropf, S., Heudobler, D., Grosse, J., Moosbauer, J., Hutterer, M., Hau, P., Riemenschneider, M. J., Bayerlova, M., Bleckmann, A., Polzer, B., Beissbarth, T., Klein, C. A., and Pukrop, T. (2018) Isolated metastasis of an EGFR-L858R-mutated NSCLC of the meninges: the potential impact of CXCL12/CXCR4 axis in EGFRmut NSCLC in diagnosis, follow-up and treatment. Oncotarget9, 18844-18857

    Lorentzen, A., Becker, P. F., Kosla, J., Saini, M., Weidele, K., Ronchi, P., Klein, C., Wolf, M. J., Geist, F., Seubert, B., Ringelhan, M., Mihic-Probst, D., Esser, K., Roblek, M., Kuehne, F., Bianco, G., O'Connor, T., Muller, Q., Schuck, K., Lange, S., Hartmann, D., Spaich, S., Gross, O., Utikal, J., Haferkamp, S., Sprick, M. R., Damle-Vartak, A., Hapfelmeier, A., Huser, N., Protzer, U., Trumpp, A., Saur, D., Vartak, N., Klein, C. A., Polzer, B., Borsig, L., and Heikenwalder, M. (2018) Single cell polarity in liquid phase facilitates tumour metastasis. Nat Commun9, 887

    Hoffmann, M., Pasch, S., Schamberger, T., Maneck, M., Mohlendick, B., Schumacher, S., Brockhoff, G., Knoefel, W. T., Izbicki, J., Polzer, B., Stoecklein, N. H., and Klein, C. A. (2018) Diagnostic pathology of early systemic cancer: ERBB2 gene amplification in single disseminated cancer cells determines patient survival in operable esophageal cancer. International journal of cancer142, 833-843

  • 2017

    Pfeil nach unten

    Schumacher, S., Bartenhagen, C., Hoffmann, M., Will, D., Fischer, J. C., Baldus, S. E., Vay, C., Fluegen, G., Dizdar, L., Vallbohmer, D., Klein, C. A., Knoefel, W. T., Stoecklein, N. H., and Mohlendick, B. (2017) Disseminated tumour cells with highly aberrant genomes are linked to poor prognosis in operable oesophageal adenocarcinoma. British journal of cancer117, 725-733

  • 2016

    Pfeil nach unten

    Suzuki, T., Asami, M., Hoffmann, M., Lu, X., Guzvic, M., Klein, C. A., and Perry, A. C. (2016) Mice produced by mitotic reprogramming of sperm injected into haploid parthenogenotes. Nat Commun7, 12676

    Hosseini, H., Obradovic, M. M., Hoffmann, M., Harper, K. L., Sosa, M. S., Werner-Klein, M., Nanduri, L. K., Werno, C., Ehrl, C., Maneck, M., Patwary, N., Haunschild, G., Guzvic, M., Reimelt, C., Grauvogl, M., Eichner, N., Weber, F., Hartkopf, A. D., Taran, F. A., Brucker, S. Y., Fehm, T., Rack, B., Buchholz, S., Spang, R., Meister, G., Aguirre-Ghiso, J. A., and Klein, C. A. (2016) Early dissemination seeds metastasis in breast cancer. Nature540, 552-558

    Harper, K. L., Sosa, M. S., Entenberg, D., Hosseini, H., Cheung, J. F., Nobre, R., Avivar-Valderas, A., Nagi, C., Girnius, N., Davis, R. J., Farias, E. F., Condeelis, J., Klein, C. A., and Aguirre-Ghiso, J. A. (2016) Mechanism of early dissemination and metastasis in Her2+ mammary cancer. Nature540, 588-592

    Alberter, B., Klein, C. A., and Polzer, B. (2016) Single-cell analysis of CTCs with diagnostic precision: opportunities and challenges for personalized medicine. Expert Rev Mol Diagn16, 25-38

  • 2015

    Pfeil nach unten

    Frances, D., Sharma, N., Pofahl, R., Maneck, M., Behrendt, K., Reuter, K., Krieg, T., Klein, C. A., Haase, I., and Niemann, C. (2015) A role for Rac1 activity in malignant progression of sebaceous skin tumors. Oncogene34, 5505-5512

    Czyz, Z. T., and Klein, C. A. (2015) Deterministic Whole-Genome Amplification of Single Cells. Methods Mol Biol1347, 69-86

  • 2014

    Pfeil nach unten

    Werner-Klein, M., Proske, J., Werno, C., Schneider, K., Hofmann, H. S., Rack, B., Buchholz, S., Ganzer, R., Blana, A., Seelbach-Gobel, B., Nitsche, U., Mannel, D. N., and Klein, C. A. (2014) Immune humanization of immunodeficient mice using diagnostic bone marrow aspirates from carcinoma patients. PloS one9, e97860

    Wang, J., Lu, X., Sakk, V., Klein, C. A., and Rudolph, K. L. (2014) Senescence and apoptosis block hematopoietic activation of quiescent hematopoietic stem cells with short telomeres. Blood124, 3237-3240

    Vay, C., Hosch, S. B., Stoecklein, N. H., Klein, C. A., Vallbohmer, D., Link, B. C., Yekebas, E. F., Izbicki, J. R., Knoefel, W. T., and Scheunemann, P. (2014) Integrin expression in esophageal squamous cell carcinoma: loss of the physiological integrin expression pattern correlates with disease progression. PloS one9, e109026

    Ulmer, A., Dietz, K., Hodak, I., Polzer, B., Scheitler, S., Yildiz, M., Czyz, Z., Lehnert, P., Fehm, T., Hafner, C., Schanz, S., Rocken, M., Garbe, C., Breuninger, H., Fierlbeck, G., and Klein, C. A. (2014) Quantitative measurement of melanoma spread in sentinel lymph nodes and survival. PLoS medicine11, e1001604

    Renner, P., Rovira, J., Klein, C., Schlitt, H. J., Geissler, E. K., and Kroemer, A. (2014) KLRG1(+) natural killer cells protect against pulmonary metastatic disease by immunosurveillance. Oncoimmunology3, e28328

    Polzer, B., Medoro, G., Pasch, S., Fontana, F., Zorzino, L., Pestka, A., Andergassen, U., Meier-Stiegen, F., Czyz, Z. T., Alberter, B., Treitschke, S., Schamberger, T., Sergio, M., Bregola, G., Doffini, A., Gianni, S., Calanca, A., Signorini, G., Bolognesi, C., Hartmann, A., Fasching, P. A., Sandri, M. T., Rack, B., Fehm, T., Giorgini, G., Manaresi, N., and Klein, C. A. (2014) Molecular profiling of single circulating tumor cells with diagnostic intention. EMBO molecular medicine6, 1371-1386

    Neves, R. P., Raba, K., Schmidt, O., Honisch, E., Meier-Stiegen, F., Behrens, B., Mohlendick, B., Fehm, T., Neubauer, H., Klein, C. A., Polzer, B., Sproll, C., Fischer, J. C., Niederacher, D., and Stoecklein, N. H. (2014) Genomic high-resolution profiling of single CKpos/CD45neg flow-sorting purified circulating tumor cells from patients with metastatic breast cancer. Clin Chem60, 1290-1297

    Guzvic, M., Braun, B., Ganzer, R., Burger, M., Nerlich, M., Winkler, S., Werner-Klein, M., Czyz, Z. T., Polzer, B., and Klein, C. A. (2014) Combined genome and transcriptome analysis of single disseminated cancer cells from bone marrow of prostate cancer patients reveals unexpected transcriptomes. Cancer research74, 7383-7394

    Czyz, Z. T., Hoffmann, M., Schlimok, G., Polzer, B., and Klein, C. A. (2014) Reliable Single Cell Array CGH for Clinical Samples. PloS one9, e85907

  • 2013

    Pfeil nach unten

    Polzer, B., and Klein, C. A. (2013) Metastasis awakening: the challenges of targeting minimal residual cancer. Nature medicine19, 274-275

    Klein, C. A. (2013) Selection and adaptation during metastatic cancer progression. Nature501, 365-372

    Hittinger, M., Czyz, Z. T., Huesemann, Y., Maneck, M., Botteron, C., Kaeufl, S., Klein, C. A., and Polzer, B. (2013) Molecular profiling of single Sca-1+/CD34+,- cells--the putative murine lung stem cells. PloS one8, e83917

    Guzvic, M., and Klein, C. A. (2013) Cancer dormancy: time to explore its clinical relevance. Breast Cancer Res15, 321

    Fischer, J. C., Niederacher, D., Topp, S. A., Honisch, E., Schumacher, S., Schmitz, N., Zacarias Fohrding, L., Vay, C., Hoffmann, I., Kasprowicz, N. S., Hepp, P. G., Mohrmann, S., Nitz, U., Stresemann, A., Krahn, T., Henze, T., Griebsch, E., Raba, K., Rox, J. M., Wenzel, F., Sproll, C., Janni, W., Fehm, T., Klein, C. A., Knoefel, W. T., and Stoecklein, N. H. (2013) Diagnostic leukapheresis enables reliable detection of circulating tumor cells of nonmetastatic cancer patients. Proceedings of the National Academy of Sciences of the United States of America110, 16580-16585

  • 2012

    Pfeil nach unten

    Luebke, A. M., Baudis, M., Matthaei, H., Vashist, Y. K., Verde, P. E., Hosch, S. B., Erbersdobler, A., Klein, C. A., Izbicki, J. R., Knoefel, W. T., and Stoecklein, N. H. (2012) Losses at chromosome 4q are associated with poor survival in operable ductal pancreatic adenocarcinoma. Pancreatology12, 16-22

    Lichtenauer, U., Shapiro, I., Sackmann, S., Drouin, J., Scheele, J., Maneck, M., Klein, C., and Beuschlein, F. (2012) The side population phenomenon enriches for designated adrenocortical progenitor cells in mice. J Endocrinol215, 383-391

    Kirsch, S., and Klein, C. A. (2012) Sequence error storms and the landscape of mutations in cancer. Proceedings of the National Academy of Sciences of the United States of America109, 14289-14290

    Cucuruz, B., Dango, S., Jurinovic, V., Mayer, O., Follo, M., Bohm, J., Freudenberg, N., Elze, M., Sienel, W., Klein, C. A., Passlick, B., and Polzer, B. (2012) MAGE qPCR improves the sensitivity and accuracy of EBUS-TBNA for the detection of lymphatic cancer spread. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer7, 690-697

  • 2011

    Pfeil nach unten

    VerMilyea, M. D., Maneck, M., Yoshida, N., Blochberger, I., Suzuki, E., Suzuki, T., Spang, R., Klein, C. A., and Perry, A. C. (2011) Transcriptome asymmetry within mouse zygotes but not between early embryonic sister blastomeres. Embo J30, 1841-1851

    Klein, C. A. (2011) Framework models of tumor dormancy from patient-derived observations. Curr Opin Genet Dev21, 42-49

    Conrad, C., Husemann, Y., Niess, H., von Luettichau, I., Huss, R., Bauer, C., Jauch, K. W., Klein, C. A., Bruns, C., and Nelson, P. J. (2011) Linking transgene expression of engineered mesenchymal stem cells and angiopoietin-1-induced differentiation to target cancer angiogenesis. Ann Surg253, 566-571

    Chambers, K. F., Pearson, J. F., Pellacani, D., Aziz, N., Guzvic, M., Klein, C. A., and Lang, S. H. (2011) Stromal upregulation of lateral epithelial adhesions: gene expression analysis of signalling pathways in prostate epithelium. J Biomed Sci18, 45

  • 2010

    Pfeil nach unten

    Stoecklein, N. H., and Klein, C. A. (2010) Genetic disparity between primary tumours, disseminated tumour cells, and manifest metastasis. International journal of cancer126, 589-598

    Eberle, J., Spangler, B., Becker, J. C., Heinemann, S. H., Klein, C. A., Kunz, M., Kuphal, S., Langer, P., Mauch, C., Meierjohann, S., Paschen, A., Schadendorf, D., Schartl, M., Schittek, B., Schonherr, R., Tuting, T., Zigrino, P., and Bosserhoff, A. K. (2010) Multicentre study on standardisation of melanoma cell culture--an initiative of the German Melanoma Research Network. Pigment Cell Melanoma Res23, 296-298

    Dango, S., Wang, X. T., Gold, M., Cucuruz, B., Klein, C. A., Passlick, B., and Sienel, W. (2010) Expression of melanoma-antigen-A (MAGE-A) in disseminated tumor cells in regional lymph nodes of patients with operable non-small cell lung cancer. Lung Cancer67, 290-295

  • 2009

    Pfeil nach unten

    Weckermann, D., Polzer, B., Ragg, T., Blana, A., Schlimok, G., Arnholdt, H., Bertz, S., Harzmann, R., and Klein, C. A. (2009) Perioperative activation of disseminated tumor cells in bone marrow of patients with prostate cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology27, 1549-1556

    Klein, C. A., and Stoecklein, N. H. (2009) Lessons from an aggressive cancer: evolutionary dynamics in esophageal carcinoma. Cancer research69, 5285-5288

    Klein, C. A., (2009) Parallel progression of primary tumours and metastases. Nat Rev Cancer9, 302-312

    Imle, A., Polzer, B., Alexander, S., Klein, C. A., and Friedl, P. (2009) Genomic instability of micronucleated cells revealed by single-cell comparative genomic hybridization. Cytometry. Part A : the journal of the International Society for Analytical Cytology75, 562-568

    Husemann, Y., and Klein, C. A. (2009) The analysis of metastasis in transgenic mouse models. Transgenic Res18, 1-5

    Hafner, C., Stoehr, R., van Oers, J. M., Zwarthoff, E. C., Hofstaedter, F., Klein, C., Landthaler, M., Hartmann, A., and Vogt, T. (2009) The absence of BRAF, FGFR3, and PIK3CA mutations differentiates lentigo simplex from melanocytic nevus and solar lentigo. The Journal of investigative dermatology129, 2730-2735

    Gires, O., Klein, C. A., and Baeuerle, P. A. (2009) On the abundance of EpCAM on cancer stem cells. Nat Rev Cancer9, 143; author reply 143

  • 2008

    Pfeil nach unten

    Stoecklein, N. H., Hosch, S. B., Bezler, M., Stern, F., Hartmann, C. H., Vay, C., Siegmund, A., Scheunemann, P., Schurr, P., Knoefel, W. T., Verde, P. E., Reichelt, U., Erbersdobler, A., Grau, R., Ullrich, A., Izbicki, J. R., and Klein, C. A. (2008) Direct genetic analysis of single disseminated cancer cells for prediction of outcome and therapy selection in esophageal cancer. Cancer cell13, 441-453

    Sienel, W., Polzer, B., Elshawi, K., Lindner, M., Morresi-Hauf, A., Vay, C., Eder, F., Passlick, B., and Klein, C. A. (2008) Cellular localization of EMMPRIN predicts prognosis of patients with operable lung adenocarcinoma independent from MMP-2 and MMP-9. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc21, 1130-1138

    Klein, C. A. (2008) The direct molecular analysis of metastatic precursor cells in breast cancer: A chance for a better understanding of metastasis and for personalised medicine. European journal of cancer

    Klein, C. A. (2008) Cancer. The metastasis cascade. Science321, 1785-1787

    Husemann, Y., Geigl, J. B., Schubert, F., Musiani, P., Meyer, M., Burghart, E., Forni, G., Eils, R., Fehm, T., Riethmuller, G., and Klein, C. A. (2008) Systemic spread is an early step in breast cancer. Cancer cell13, 58-68

    Hahtola, S., Burghart, E., Puputti, M., Karenko, L., Abdel-Rahman, W. M., Vakeva, L., Jeskanen, L., Virolainen, S., Karvonen, J., Salmenkivi, K., Kinnula, V., Joensuu, H., Peltomaki, P., Klein, C. A., and Ranki, A. (2008) Cutaneous T-cell lymphoma-associated lung cancers show chromosomal aberrations differing from primary lung cancer. Genes Chromosomes Cancer47, 107-117

    Hahtola, S., Burghart, E., Jeskanen, L., Karenko, L., Abdel-Rahman, W. M., Polzer, B., Kajanti, M., Peltomaki, P., Pettersson, T., Klein, C. A., and Ranki, A. (2008) Clinicopathological characterization and genomic aberrations in subcutaneous panniculitis-like T-cell lymphoma. The Journal of investigative dermatology128, 2304-2309

    Fuhrmann, C., Schmidt-Kittler, O., Stoecklein, N. H., Petat-Dutter, K., Vay, C., Bockler, K., Reinhardt, R., Ragg, T., and Klein, C. A. (2008) High-resolution array comparative genomic hybridization of single micrometastatic tumor cells. Nucleic Acids Res36, e39

  • 2007

    Pfeil nach unten

    Weckermann, D., Polzer, B., and Klein, C. (2007) [Significance of cytokeratin positive cells in the bone marrow of patients with clinical localized prostate cancer]. Der Urologe. Ausg. A46, 1078-1080

  • 2006

    Pfeil nach unten

    Yekebas, E. F., Bogoevski, D., Bubenheim, M., Link, B. C., Kaifi, J. T., Wachowiak, R., Mann, O., Kutup, A., Cataldegirmen, G., Wolfram, L., Erbersdobler, A., Klein, C., Pantel, K., and Izbicki, J. R. (2006) Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy. World J Gastroenterol12, 6515-6521

    Klein, C. A., and Holzel, D. (2006) Systemic cancer progression and tumor dormancy: mathematical models meet single cell genomics. Cell cycle5, 1788-1798

    Klein, C. A. (2006) Random mutations, selected mutations: a PIN opens the door to new genetic landscapes. Proceedings of the National Academy of Sciences of the United States of America103, 18033-18034

    Hartmann, C. H., and Klein, C. A. (2006) Gene expression profiling of single cells on large-scale oligonucleotide arrays. Nucleic Acids Res34, e143

    Bahar, R., Hartmann, C. H., Rodriguez, K. A., Denny, A. D., Busuttil, R. A., Dolle, M. E., Calder, R. B., Chisholm, G. B., Pollock, B. H., Klein, C. A., and Vijg, J. (2006) Increased cell-to-cell variation in gene expression in ageing mouse heart. Nature441, 1011-1014

  • 2005

    Pfeil nach unten

    Wang, X. T., Sienel, W., Eggeling, S., Ludwig, C., Stoelben, E., Mueller, J., Klein, C. A., and Passlick, B. (2005) Detection of disseminated tumor cells in mediastinoscopic lymph node biopsies and lymphadenectomy specimens of patients with NSCLC by quantitative RT-PCR. Eur J Cardiothorac Surg28, 26-32

    Ulmer, A., Fischer, J. R., Schanz, S., Sotlar, K., Breuninger, H., Dietz, K., Fierlbeck, G., and Klein, C. A. (2005) Detection of melanoma cells displaying multiple genomic changes in histopathologically negative sentinel lymph nodes. Clin Cancer Res11, 5425-5432

    Schardt, J. A., Meyer, M., Hartmann, C. H., Schubert, F., Schmidt-Kittler, O., Fuhrmann, C., Polzer, B., Petronio, M., Eils, R., and Klein, C. A. (2005) Genomic analysis of single cytokeratin-positive cells from bone marrow reveals early mutational events in breast cancer. Cancer cell8, 227-239

    Klein, C. A., Zohlnhofer, D., Petat-Dutter, K., and Wendler, N. (2005) Gene expression analysis of a single or few cells. Curr Protoc Hum GenetChapter 11, Unit 11 18

    Klein, C. A. (2005) Single cell amplification methods for the study of cancer and cellular ageing. Mech Ageing Dev126, 147-151

  • 2004

    Pfeil nach unten

    Ulmer, A., Schmidt-Kittler, O., Fischer, J., Ellwanger, U., Rassner, G., Riethmuller, G., Fierlbeck, G., and Klein, C. A. (2004) Immunomagnetic enrichment, genomic characterization, and prognostic impact of circulating melanoma cells. Clin Cancer Res10, 531-537

    Stoecklein, N. H., Luebke, A. M., Erbersdobler, A., Knoefel, W. T., Schraut, W., Verde, P. E., Stern, F., Scheunemann, P., Peiper, M., Eisenberger, C. F., Izbicki, J. R., Klein, C. A., and Hosch, S. B. (2004) Copy number of chromosome 17 but not HER2 amplification predicts clinical outcome of patients with pancreatic ductal adenocarcinoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology22, 4737-4745

    Klein, C. A. (2004) Gene expression sigantures, cancer cell evolution and metastatic progression. Cell cycle3, 29-31

  • 2003

    Pfeil nach unten

    Sienel, W., Hellers, J., Morresi-Hauf, A., Lichtinghagen, R., Mutschler, W., Jochum, M., Klein, C., Passlick, B., and Pantel, K. (2003) Prognostic impact of matrix metalloproteinase-9 in operable non-small cell lung cancer. International journal of cancer103, 647-651

    Schmidt-Kittler, O., Ragg, T., Daskalakis, A., Granzow, M., Ahr, A., Blankenstein, T. J., Kaufmann, M., Diebold, J., Arnholdt, H., Muller, P., Bischoff, J., Harich, D., Schlimok, G., Riethmuller, G., Eils, R., and Klein, C. A. (2003) From latent disseminated cells to overt metastasis: genetic analysis of systemic breast cancer progression. Proceedings of the National Academy of Sciences of the United States of America100, 7737-7742

    Klein, C. A. (2003) [From single disseminated tumor cells to metastasis insights from molecular genetic analyses of single cells]. Verh Dtsch Ges Pathol87, 158-164

    Klein, C. A. (2003) The systemic progression of human cancer: a focus on the individual disseminated cancer cell--the unit of selection. Adv Cancer Res89, 35-67

    Jentsch, I., Geigl, J., Klein, C. A., and Speicher, M. R. (2003) Seven-fluorochrome mouse M-FISH for high-resolution analysis of interchromosomal rearrangements. Cytogenet Genome Res103, 84-88

  • 2002

    Pfeil nach unten

    Stoecklein, N. H., Erbersdobler, A., Schmidt-Kittler, O., Diebold, J., Schardt, J. A., Izbicki, J. R., and Klein, C. A. (2002) SCOMP is superior to degenerated oligonucleotide primed-polymerase chain reaction for global amplification of minute amounts of DNA from microdissected archival tissue samples. Am J Pathol161, 43-51

    Klein, C. A., Wilke, M., Pool, J., Vermeulen, C., Blokland, E., Burghart, E., Krostina, S., Wendler, N., Passlick, B., Riethmueller, G., and Goulmy, E. (2002) The hematopoietic system-specific minor histocompatibility antigen HA-1 shows aberrant expression in epithelial cancer cells. J Exp Med196, 359-368

    Klein, C. A., Seidl, S., Petat-Dutter, K., Offner, S., Geigl, J. B., Schmidt-Kittler, O., Wendler, N., Passlick, B., Huber, R. M., Schlimok, G., Baeuerle, P. A., and Riethmuller, G. (2002) Combined transcriptome and genome analysis of single micrometastatic cells. Nat Biotechnol20, 387-392

    Klein, C. A., Blankenstein, T. J., Schmidt-Kittler, O., Petronio, M., Polzer, B., Stoecklein, N. H., and Riethmuller, G. (2002) Genetic heterogeneity of single disseminated tumour cells in minimal residual cancer. Lancet360, 683-689

    Klein, C. A. (2002) [Direct molecular analysis of single disseminated cancer cells: a prerequisite for the development of adjuvant therapies?]. Acta Med Austriaca Suppl59, 10-13

  • 2001

    Pfeil nach unten

    Zohlnhofer, D., Richter, T., Neumann, F., Nuhrenberg, T., Wessely, R., Brandl, R., Murr, A., Klein, C. A., and Baeuerle, P. A. (2001) Transcriptome analysis reveals a role of interferon-gamma in human neointima formation. Mol Cell7, 1059-1069

    Zohlnhofer, D., Klein, C. A., Richter, T., Brandl, R., Murr, A., Nuhrenberg, T., Schomig, A., Baeuerle, P. A., and Neumann, F. J. (2001) Gene expression profiling of human stent-induced neointima by cDNA array analysis of microscopic specimens retrieved by helix cutter atherectomy: Detection of FK506-binding protein 12 upregulation. Circulation103, 1396-1402

    Riethmuller, G., and Klein, C. A. (2001) Early cancer cell dissemination and late metastatic relapse: clinical reflections and biological approaches to the dormancy problem in patients. Semin Cancer Biol11, 307-311

  • 2000

    Pfeil nach unten

    Klein, C. A. (2000) The biology and analysis of single disseminated tumour cells. Trends Cell Biol10, 489-493

  • 1999

    Pfeil nach unten

    Riethmuller, G., Klein, C. A., and Pantel, K. (1999) Hunting down the seminal cells of clinical metastases. Immunol Today20, 294-296

    Klein, C. A., Schmidt-Kittler, O., Schardt, J. A., Pantel, K., Speicher, M. R., and Riethmuller, G. (1999) Comparative genomic hybridization, loss of heterozygosity, and DNA sequence analysis of single cells. Proceedings of the National Academy of Sciences of the United States of America96, 4494-4499