Publikationen AG Werner-Klein

Werner-Klein M, Grujovic A, Irlbeck C, Obradovic M, Hoffmann M, Körkel-Qu H, Lu X, Treitschke S, Köstler C, Botteron C, Weidele K, Werno C, Polzer B, Kirsch S, Gužvić M, Warfsmann J, Honarnejad K, Czyz Z, Feliciello G, Blochberger I, Grunewald S, Schneider E, Haunschild G, Patwary N, Guetter S, Huber S, Harbeck N, Rack B, Buchholz S, Rümmele P, Heine N, Rose-John S and Klein CA. Interleukin-6 trans-signaling is a candidate mechanism to drive progression of human DCCs during clinical latency. Nature Communications 2020, DOI: 10.1038/s41467-020-18701-4.

Werner-Klein M, and Klein CA. Therapy resistance beyond cellular dormancy. Nature Cell Biology 2019, DOI: 10.1038/s41556-019-0276-7.

Boscheinen JB, Thomann S, Knipe DM, DeLuca N, Schuler-Thurner B, Gross S, Dörrie J, Schaft N, Bach C, Rohrhofer A, Werner-Klein M, Schmidt B, Schuster P. Generation of an Oncolytic Herpes Simplex Virus 1 Expressing Human MelanA. Frontiers in Immunology 2019.  DOI: 10.3389/fimmu.2019.00002.

Werner-Klein M, Scheitler S, Hoffmann M, Hodak I, Dietz K, Lehnert P, Naimer V, Polzer B, Treitschke S, Werno C, Markiewicz A, Weidele K, Czyz Z, Hohenleutner U, Hafner C, Haferkamp S, Berneburg M, Rümmele P, Ulmer A and Klein CA. Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma. Nature Communications 2018, DOI: 10.1038/s41467-017-02674-y.

Ulmer A, Dietz K, Werner-Klein M, Häfner H-M, Schulz C, Renner P, Weber F, Breuninger H, Röcken M, Garbe C, Fierlbeck G, Klein CA. The sentinel lymph node spread determines quantitatively melanoma seeding to non-sentinel lymph nodes and survival. Eur J Cancer 2018, DOI: 10.1016/j.ejca.2017.12.002.

Yu Y, Schleich K, Yue B, Ji S, Lohneis P,Kemper K, Silvis MS, Qutob N, van Rooijen E, Werner-Klein M, Li L, Dhawan D, Meierjohann S, Reimann M, Elkahloun A, Treitschke S, Dörken B, Speck C, Mallette FA, Zon LI, Holmen SL, Peeper DS, Samuels Y, Schmitt CA and Lee S. Targeting the Senescence-overriding cooperative activity of structurally unrelated H3K9 demethylase in melanoma. Cancer Cell 2018, DOI: 10.1016/j.ccell.2018.03.009.

Hosseini H, Obradović M, Hoffmann M, Harper K, Soledad Sosa M, Werner-Klein M, Nanduri L, Werno C, Ehrl C, Maneck M, Patwary N, Haunschild G, Gužvić M, Reimelt C, Grauvogl M, Eichner N, Weber F, Hartkopf A, Taran F-A, Brucker SY, Fehm T, Rack B, Buchholz S, Spang R, Meister G, Aguirre-Ghiso JA,Klein C. Early dissemination seeds metastasis in breast cancer. Nature 2016, DOI:10.1038/nature20785.

Guzvic M, Braun B, Ganzer R, Burger M, Nerlich M, Winkler S, Werner-Klein M, Czyz ZT, Polzer B, and Klein CA. Combined genome and transcriptome analysis of single disseminated cancer cells from bone marrow of prostate cancer patients reveals unexpected transcriptomes. Cancer Research 2014, DOI: 10.1158/0008-5472.CAN-14-0934.

Werner-Klein M, Proske J, Werno C, Schneider K, Hofmann HS, Rack B, Buchholz S, Ganzer R, Blana A, Seelbach-Göbel B, Nitsche U, Männel DN, Klein CA. Immune humanization of immunodeficient mice using diagnostic bone marrow aspirates from carcinoma patients. PLoS One 2014, DOI: 10.1371/journal.pone.0097860

Duechs M, Hahn C, Benediktus E, Werner-Klein M, Gantner F and Erb KJ. TLR-agonist mediated suppression of asthmatic-responses is associated with increased innate inflammation in the airways. Pulm Pharmacol Ther 2011, DOI: 10.1016/j.pupt.2010.12.009.

Werner-Klein M, Goeggel R, Westhof A, Erb KJ. Development and characterization of a novel and rapid lung eosinophil influx model in the rat. Pulm Pharmacol Ther 2008, DOI: 10.1016/j.pupt.2008.03.002.

Werner-Klein M, Dresch C, Marconi P, Brocker T. Transcriptional targeting of B cells for induction of peripheral CD8 T cell tolerance. J Immunol 2007, DOI: 10.4049/jimmunol.178.12.7738.

Trujillo-Vargas CM, Werner-Klein M, Wohlleben G, Polte T, Hansen G, Ehlers S, Erb KJ. Helminth-derived products inhibit the development of allergic responses in mice. Am J Respir Crit Care Med 2007, DOI: 10.1164/rccm.200601-054OC.

Werner-Klein M, Kalkbrenner F, and Erb KJ. Sublingual immunotherapy of allergic diseases. Expert Opin Drug Deliv 2006, DOI: 10.1517/17425247.3.5.599.

Patole PS, Schubert S, Hildinger K, Khandoga S, Khandoga A, Segerer S, Henger A, Kretzler M, Werner M, Krombach F, Schlöndorff D, Anders HJ. Toll-like receptor-4: renal cells and bone marrow cells signal for neutrophil recruitment during pyelonephritis. Kidney Int 2005, DOI: 10.1111/j.1523-1755.2005.00729.x.

Werner M, Kraunus J, Baum C and Brocker T. B-cell-specific transgene expression using a self-inactivating retroviral vector with human CD19 promoter and viral post-transcriptional regulatory element. Gene Ther 2004,  DOI: 10.1038/sj.gt.3302255.

Berg RW, Werner M, Ferguson PJ, Postenka C, Vincent M, Koropatnick DJ, Behrend E. Tumor growth inhibition in vivo and G2/M cell cycle arrest induced by antisense oligodeoxynucleotide targeting thymidylate synthase. J Pharmacol Exp Ther 2001, PMID: 11454908